Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography–mass spectrometry

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• 作者：Hoi Sim Nancy Lee ; Chanbasha Basheer and Hian Kee Lee
• 关键词：Hollow fibre ; Liquid-phase microextraction ; Chemical warfare agents ; Gas chromatography– ; mass spectrometry
• 刊名：Journal of Chromatography A
• 出版年：2006
• 出版时间：18 August 2006
• 年：2006
• 卷：1124
• 期：1-2
• 页码：91-96
• 全文大小：325 K

文摘

A simple and solvent-minimised sample preparation technique based on hollow fibre-protected liquid-phase microextraction was investigated for the gas chromatography/mass spectrometric analysis of chemical warfare agents in water and slurry samples. The chemical warfare agents included four nerve agents and a blister agent. Parameters such as extraction solvent, salt concentration, stirring speed and extraction time were optimised using spiked deionised water samples. The technique provided a linear range of two orders of magnitude, good repeatability (RSDs < 10 % , n = 6), good linearity (r² ≥ 0.995) and limits of detection (LODs) in the range of 0.02–0.09 μg l⁻¹ (S/N = 3) under full scan mode. The optimised technique was also applied to more complex slurry samples and similar precision (RSD < 15 % , n = 3) and limits of detection (0.02–0.2 μg l⁻¹, S/N = 3) were obtained.