AmTAR2: Functional characterization of a honeybee tyramine receptor stimulating adenylyl cyclase activity

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• 作者：Tina Reim^a ; Sabine Balfanz^b ; Arnd Baumann^b ; Wolfgang Blenau^c ; Markus Thamm^a ; ^d ; Ricarda Scheiner^a ; ^d ; ^{ricarda.scheiner@uni-wuerzburg.de}
• 关键词：Behavior ; Biogenic amines ; Cellular signaling ; GPCR ; Honeybee ; Second messenger
• 刊名：Insect Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：80
• 期：Complete
• 页码：91-100
• 全文大小：1904 K
• 卷排序：80

文摘

The honeybee genome contains two genes encoding tyramine receptors. We functionally characterized the second honeybee tyramine receptor, AmTAR2, in flpTM cells. AmTAR2 displays pronounced preference for tyramine over octopamine. AmTAR2 exclusively induces cAMP synthesis upon activation. AmTAR2 is effectively blocked by mianserin and yohimbine.