Heterogeneous Phenotype of Long QT Syndrome Caused by the KCNH2-H562R Mutation: Importance of Familial Genetic Testing

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• 作者：Carmen Muñ ; oz-Esparza^a ; Esperanza Garcí ; a-Molina^b ; Mariela Salar-Alcaraz^a ; Pablo Peñ ; afiel-Verdú ; ^a ; Juan J. Sá ; nchez-Muñ ; oz^a ; Juan Martí ; nez Sá ; nchez^a ; Valentí ; n Cabañ ; as-Perianes^c ; Mariano Valdé ; s Chá ; varri^a ; Arcadio Garcí ; a Alberola^a ; Juan R. Gimeno-Blanes^a ; ^{jgimeno@secardiologia.es" class="auth_mail" title="E-mail the corresponding author}
• 关键词：KCNH2 gene ; Long QT syndrome ; Sudden death
• 刊名：Revista Española de Cardiología (English Edition)
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：68
• 期：10
• 页码：861-868
• 全文大小：1731 K

文摘

Long QT syndrome is an inherited ion channelopathy that leads to syncope and sudden death. Because of the heterogeneous phenotype of this disease, genetic testing is fundamental to detect individuals with concealed long QT syndrome. In this study, we determined the features of a family with 13 carriers of the KCNH2-H562R missense mutation, which affects the pore region of the HERG channel.

Methods

We identified the KCNH2-H562R mutation in a 65-year-old man with a prolonged QTc interval who had experienced an episode of torsade de pointes. Subsequently, a total of 13 mutation carriers were identified in the family. Carriers (age 48 [26] years; 46% males) underwent clinical evaluation, electrocardiography and echocardiography.

Results

The mean (standard deviation) QTc in carriers was 493 (42) ms (3 [23%] showed normal QTc); 6 (46%) had symptoms (4, syncope; 1, sudden death; 1, aborted sudden death [proband]). While under treatment with beta-blockers, 11 of 12 carriers (92%) remained asymptomatic at 5 years of follow-up (1 patient required left cardiac sympathectomy). The QTc shortening with beta-blockers was 50 (37) ms. There was 1 sudden death in a patient who refused treatment.

Conclusions

Family study is essential in the interpretation of a genetic testing result. This article describes the heterogeneous and variable phenotype of a large family with the KCNH2-H562R mutation and highlights the role of genetic study for the appropriate identification of at-risk individuals who would benefit from treatment.