Up-regulation of FGF23 release by aldosterone
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- 作者：Bingbing Zhanga ; Anja T. Umbacha ; Hong Chena ; Jing Yana ; Hajar Fakhria ; Abul Fajola ; Madhuri S. Salkera ; Daniela Spichtigb ; c ; Arezoo Daryadelb ; c ; Carsten A. Wagnerb ; c ; Michael Fö ; llerd ; Florian Langa ; florian.lang@uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：1 ; 25(OH)2D3 ; Mineralocorticoid ; Spironolactone ; SOCE ; Calcium ; Orai1 ; NFκB
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：470
- 期：2
- 页码：384-390
- 全文大小：1194 K
文摘
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DOCA treatment and salt depletion of mice increases serum FGF23 concentration.
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In osteoblasts aldosterone enhances and spironolactone decreases Ca2+ entry (SOCE).
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Aldosterone increases FGF23 transcript levels in osteoblasts.
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The effect of aldosterone is blunted by mineralocorticoid receptor blockers.
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The aldosterone effect is blunted by inhibition of SGK1, NFκB or Ca2+ channels.