Radiographic progression of knee osteoarthritis is associated with MRI abnormalities in both the patellofemoral and tibiofemoral joint

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• 作者：B.J.E. de Lange-Brokaar^&dagger ; ; ^{b.j.e.de_lange@lumc.nl" class="auth_mail" title="E-mail the corresponding author} ; J. Bijsterbosch^&dagger ; ; P.R. Kornaat^&Dagger ; ; E. Yusuf^&dagger ; ; A. Ioan-Facsinay^&dagger ; ; A.-M. Zuurmond^§ ; ; H.M. Kroon^‖ ; I. Meulenbelt^&para ; ; J.L. Bloem^‖ ; M. Kloppenburg^&dagger ; ; ^#
• 关键词：Osteoarthritis ; Synovitis ; Radiographic progression
• 刊名：Osteoarthritis and Cartilage
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：24
• 期：3
• 页码：473-479
• 全文大小：242 K

文摘

To investigate patterns of MRI abnormalities in the patellofemoral (PFJ) and tibiofemoral joint (TFJ) and their association with radiographic progression, using hypothesis free analyses.

Design

ra0015">205 patients from the GARP study with symptomatic OA at multiple sites (mean age 60 years, 80% woman, median BMI 26 kg/m²), underwent knee MRI at baseline. Cartilage damage, osteophytes, cysts, bone marrow lesions (BMLs) and effusion/synovitis were scored according to a validated scoring method. Baseline and 6-year TFJ and PFJ radiographs were scored (0–3) for JSN and osteophytes according to OARSI and Burnett atlases, respectively; progression was defined as ≥1 point increase. Baseline patterns of MRI abnormalities derived from principal component analysis (PCA) were associated with progression using adjusted generalized estimating equations (GEE).

Results

ra0020">PCA resulted in extraction of six components, explaining 69% of variance. In 29% and 29% of 133 patients with follow-up the TFJ progressed, whereas in 15% and 9% the PFJ progressed for osteophytes and JSN, respectively. Component 1 (cartilage damage of the PFJ and osteophytes of both joints) was statistically significant associated with TFJ JSN progression and PFJ osteophyte progression. Component 2 (all lateral PFJ abnormalities except osteophytes) was associated with JSN/osteophyte progression in the PFJ alone, whereas component 3 (all medial TFJ abnormalities except osteophytes) was associated with JSN and osteophyte progression in both PFJ and TFJ.

Conclusion

ra0025">Baseline structural damage and bone turnover activity, as reflected by BMLs, seem to be involved in knee OA progression. Moreover, progression in PFJ and TFJ seems to be related.