Molecular diagnosis of bloodstream infections in onco-haematology patients with PCR/ESI-MS technology

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• 作者：Elena Jordana-Lluch^a ; ^b ; ^g ; Belé ; n Rivaya^a ; Clara Marcó ; ^a ; Montserrat Gimé ; nez^a ; ^b ; Mª ; Dolores Quesada^a ; Agustí ; n Escobedo^c ; Montserrat Batlle^d ; Elisa Martró ; ^a ; ^e ; ^f ; ^h ; ^{emartro@igtp.cat} ; Vicente Ausina^a ; ^b ; ^h
• 关键词：Bloodstream infection ; Molecular diagnosis ; Oncology ; Haematology ; PCR/ESI-MS
• 刊名：Journal of Infection
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：74
• 期：2
• 页码：187-194
• 全文大小：468 K
• 卷排序：74

文摘

This is the first evaluation of IRIDICA for the molecular diagnosis of sepsis in both oncology and haematology patients. IRIDICA detected 44 relevant microorganisms not isolated by culture and missed 31. IRIDICA showed better sensitivity in oncological than in haematological patients (81.3 vs. 71.4%, by specimen). The use of IRIDICA could lead to an earlier administration of targeted antibiotic therapy, especially in oncology patients.