- 作者：Neil J. Friedman MD<sup> ; sup><sup>asup><sup> ; sup><sup>njfmd@pol.net"" rel=""nofollowsup> ; Daniel V. Palanker PhD<sup>asup> ; Georg Schuele PhD<sup>asup> ; Dan Andersen MS<sup>asup> ; George Marcellino PhD<sup>asup> ; Barry S. Seibel MD<sup>asup> ; Juan Batlle MD<sup>asup> ; Rafael Feliz MD<sup>asup> ; Jonathan H. Talamo MD<sup>asup> ; Mark S. Blumenkranz MD<sup>asup> ; William W. Culbertson MD<sup>asup> [Author vitae]
- 刊名：Journal of Cataract and Refractive Surgery
- 出版年：2011
- 出版时间：July 2011
- 年：2011
- 卷：37
- 期：7
- 页码：1189-1198
- 全文大小：1201 K
ss=""h4"">Purpose
To evaluate a femtosecond laser system to create the capsulotomy.ss=""h4"">Setting
Porcine and cadaver eye studies were performed at OptiMedica Corp., Santa Clara, California, USA; the human trial was performed at the Centro Laser, Santo Domingo, Dominican Republic.
ss=""h4"">Design
Experimental and clinical study.
ss=""h4"">Methods
Capsulotomies performed by an optical coherence tomography–guided femtosecond laser were evaluated in porcine and human cadaver eyes. Subsequently, the procedure was performed in 39 patients as part of a prospective randomized study of femtosecond laser-assisted cataract surgery. The accuracy of the capsulotomy size, shape, and centration were quantified and capsulotomy strength was assessed in the porcine eyes.
ss=""h4"">Results
Laser-created capsulotomies were significantly more precise in size and shape than manually created capsulorhexes. In the patient eyes, the deviation from the intended diameter of the resected capsule disk was 29 μm ± 26 (SD) for the laser technique and 337 ± 258 μm for the manual technique. The mean deviation from circularity was 6 % and 20 % , respectively. The center of the laser capsulotomies was within 77 ± 47 μm of the intended position. All capsulotomies were complete, with no radial nicks or tears. The strength of laser capsulotomies (porcine subgroup) decreased with increasing pulse energy: 152 ± 21 mN for 3 μJ, 121 ± 16 mN for 6 μJ, and 113 ± 23 mN for 10 μJ. The strength of the manual capsulorhexes was 65 ± 21 mN.
ss=""h4"">Conclusion
The femtosecond laser produced capsulotomies that were more precise, accurate, reproducible, and stronger than those created with the conventional manual technique.
ss=""h4"">Financial Disclosure
The authors have equity interest in OptiMedica Corp., which manufactures the femtosecond laser cataract system.