Irradiation-induced secretion of BMP4 by marrow cells causes marrow adipogenesis post-myelosuppression

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• 作者：Manmohan S. Bajaj ; Rohan S. Kulkarni¹ ; Suprita S. Ghode¹ ; Lalita S. Limaye ; Vaijayanti P. Kale ; ^{vpkale@nccs.res.in} ; ^{vaijayanti.kale@gmail.com}
• 关键词：BMP4 ; Simvastatin ; Marrow adipogenesis ; Bone marrow cells ; PPAR-γ ; Irradiation ; Hematopoietic recovery
• 刊名：Stem Cell Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：17
• 期：3
• 页码：646-653
• 全文大小：1172 K
• 卷排序：17

文摘

Marrow tissue responds to irradiation with de novo expression and secretion of BMP4. BMP4 irreversibly commits marrow MSCs to adipogenic lineage. Simvastatin prevents BMP4-induced BM adipogenesis by inhibiting Ppar-γ expression. Simvastatin does not interfere with irradiation-induced BMP4 secretion.