Pseudo four-component reaction of salicylaldehydes and cyclic ketones with two molecules of malononitrile: A facile and efficient way to synthesize 4-[2-(dicyanomethylene)cyclic or heterocyclic]-2-amino-4H-chromenes

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• 作者：Michail N. Elinson ; ^{elinson@ioc.ac.ru" class="auth_mail" title="E-mail the corresponding author} ; Anatoly N. Vereshchagin ; Sergey I. Bobrovsky ; Ruslan F. Nasybullin ; Alexey I. Ilovaisky ; Valentina M. Merkulova
• 关键词：Multicomponent reaction ; Salicylaldehyde ; Cyclic ketone ; Malononitrile ; Pseudo four-component reaction ; 2-Amino-4H-chromene
• 刊名：Comptes Rendus Chimie
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：19
• 期：3
• 页码：293-298
• 全文大小：390 K

文摘

A new type of catalytic cascade pseudo four-component reaction has been found. The simple and facile pseudo four-component reaction of salicylaldehydes and cyclic or heterocyclic ketones with two molecules of malononitrile catalyzed by sodium acetate at ambient temperature results in the formation of 4-substituted 2-amino-4H-chromenes in 70–90% yields. Thus, a new simple and efficient ‘one-pot’ method to synthesize substituted 2-amino-4H-chromenes was found directly from such reasonable starting compounds as salicylaldehydes, cyclic or heterocyclic ketones and malononitrile.