Recurrent wheezing and asthma after bocavirus bronchiolitis

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• 作者：T. del Rosal^a ; M.L. Garcí ; a-Garcí ; a^b ; ^{marialuz.hso@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; C. Calvo^b ; F. Gozalo^b ; F. Pozo^c ; I. Casas^c
• 关键词：Human bocavirus ; Bronchiolitis ; Asthma ; Recurrent wheezing
• 刊名：Allergologia et Immunopathologia
• 出版年：2016
• 出版时间：September-October 2016
• 年：2016
• 卷：44
• 期：5
• 页码：410-414
• 全文大小：390 K

文摘

Human bocavirus (HBoV) was recently discovered and identified as an important cause of respiratory infection in young children. However, the relationship between HBoV-bronchiolitis and the development of recurrent wheezing has not yet been established.

Objective

We designed this study in order to describe the mid-term outcome, regarding the development of recurrent wheezing and asthma of HBoV-bronchiolitis patients and to compare it with RSV-bronchiolitis infants.

Methods

We studied 80 children (10 with HBoV and 70 with RSV infection), currently aged ≥4 years and previously hospitalised during the seasons 2004–2009 due to acute bronchiolitis. Epidemiological and clinical data were collected through structured clinical interviews at the follow-up visit. Spirometry and skin prick tests to common food and inhaled allergens were performed.

Results

All HBoV-patients developed recurrent wheezing and half of them had asthma at age 5–7 years. Almost 30% required hospital admission for recurrent wheezing. Asthma (odds ratio (OR) = 1.28) and current asthma (OR = 2.18) were significantly more frequent in children with HBoV-bronchiolitis than in RSV-bronchiolitis. FEV₁ values were 99.2 ± 4.8 in HBoV-group vs. 103 ± 11 in RSV-group, p: 0.09. No differences were found with respect to allergic rhinitis, atopic dermatitis, food allergy, proportion of positive prick tests, and family history of atopy or asthma.

Conclusions

Severe HBoV-bronchiolitis in infancy was strongly associated with asthma at 5–7 years.