Nuclear microprobe investigation of the penetration of ultrafine zinc oxide into intact and tape-stripped human skin

详细信息    查看全文

• 作者：Z. Szikszai ; Zs. Kert&#xe9 ; sz ; E. Bodn&#xe1 ; r ; I. Major ; I. Borb&#xed ; ró ; Á ; .Z. Kiss ; J. Hunyadi
• 关键词：Ion microscopy ; PIXE ; STIM ; Sunscreens ; ZnO nanoparticles ; Penetration into human skin ; Tape-stripped skin
• 刊名：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：268
• 期：11-12
• 页码：2160-2163
• 全文大小：1120 K

文摘

Ultrafine metal oxides, such as titanium dioxide and zinc oxide are widely used in cosmetic and health products like sunscreens. These oxides are potent UV filters and the small particle size makes the product more transparent compared to formulations containing coarser particles. In the present work the penetration of ultrafine zinc oxide into intact and tape-stripped human skin was investigated using nuclear microprobe techniques, such as proton induced X-ray spectroscopy and scanning transmission ion microscopy. Our results indicate that the penetration of ultrafine zinc oxide, in a hydrophobic basis gel with 48 h application time, is limited to the stratum corneum layer of the intact skin. Removing the stratum corneum partially or entirely by tape-stripping did not cause the penetration of the particles into the deeper dermal layers; the zinc particles remained on the surface of the skin.