Increased production of asymmetric dimethylarginine (ADMA) in ankylosing spondylitis: Association with other clinical and laboratory parameters

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• 作者：Á ; d&#xe1 ; m Kem&#xe9 ; ny-Beke^a ; Rudolf Gesztelyi^b ; Nó ; ra Bodn&#xe1 ; r^c ; Judit Zsuga^d ; Gyö ; rgy Kerekes^e ; Mikló ; s Zsuga^f ; Bernadett Biri^f ; S&#xe1 ; ndor K&#xe9 ; ki^f ; P&#xe9 ; ter Szodoray^g ; Andr&#xe1 ; s Berta^a ; Zolt&#xe1 ; n Szekanecz^c ; ^{szekanecz.zoltan@med.unideb.hu} ; ^{szekanecz@hotmail.com} ; S&#xe1 ; ndor Sz&#xe1 ; ntó ; ^c
• 关键词：Ankylosing spondylitis ; ADMA ; Atherosclerosis ; Cardiovascular disease
• 刊名：Joint Bone Spine
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：78
• 期：2
• 页码：184-187
• 全文大小：184 K

文摘

Objective

Asymmetric dimethylarginine (ADMA) has been associated with atherosclerosis, vascular diseases and, recently, also with arthritis including rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

Methods

Serum ADMA, arginine and symmetric dimethylarginine (SDMA) levels were assessed by liquid chromatography in 61 AS and 26 osteoarthritis (OA) patients with no known cardiovascular disease.

Results

Serum ADMA levels were significantly increased in AS compared to OA patients (0.95 ± 0.17 μM versus 0.70 ± 0.25 μM; p < 0.001). There were no differences in serum arginine and SDMA levels. Serum ADMA levels also positively correlated with age (R = 0.258; p = 0.043), body mass index (R = 0.368; p = 0.003), erythrocyte sedimentation rate (R = 0.329; p = 0.009) and ADMA levels negative correlated with chest expansion (R = −0.251; p = 0.04). No correlations were found between ADMA levels and disease duration, pain intensity, BASDAI, BASFI, BASMI, quality of life, CRP, HLA-B27 positivity, endothelial dysfunction or carotid atherosclerosis.

Conclusion

ADMA may serve as a marker of systemic inflammation and may reflect functional immobility in AS. Further studies are needed to assess the possible role of ADMA in AS and AS-related vascular disease.