Synthesis of 2-oxo-2,3,5,6-tetrahydro-5-thioxoimidazo[1,2-c]quinazolines by one-pot cyclization of α-aminocarboxylic esters with 2-(isothiocyanato)benzonitrile (ITCB)
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- 作者：Anja Bodtke ; Helmut Reinke ; Dirk Michalik and Peter Langer
- 关键词：Amino acids ; Cyclizations ; Domino reactions ; Isothiocyanates ; Regioselectivity
- 刊名：Tetrahedron
- 出版年：2006
- 出版时间：14 August 2006
- 年：2006
- 卷：62
- 期：33
- 页码：7653-7660
- 全文大小：380 K
文摘
The cyclization of 2-(isothiocyanato)benzonitrile with α-aminocarboxylic esters and acids afforded a variety of 2-oxo-2,3,5,6-tetrahydro-5-thioxo-imidazo[1,2-c]quinazolines with very good regioselectivity.