Effect of BMI and body weight on pregnancy rates with LNG as emergency contraception: analysis of four WHO HRP studies

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• 作者：Mario Philip R. Festin^a ; ^{festinma@who.int} ; ^{mfestinmd@gmail.com} ; Alexandre Peregoudov^a ; ^{sasha.np@gmail.com} ; Armando Seuc^a ; ^{armandoseuc@infomed.sld.cu} ; James Kiarie^a ; ^{kiariej@who.int} ; Marleen Temmerman^b ; ^{marleen.temmerman@aku.edu}
• 关键词：Emergency contraception ; Hormonal contraception ; Levonorgestrel ; Body weight ; Body mass index (BMI)
• 刊名：Contraception
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：95
• 期：1
• 页码：50-54
• 全文大小：155 K
• 卷排序：95

文摘

To estimate the effect of increased body weight and body mass index (BMI) on pregnancy rates with levonorgestrel (LNG) 1.5 mg used as emergency contraception (EC).MethodsThe study reviewed data from 6873 women in four WHO-HRP randomized trials on EC conducted between 1993 and 2010. Participants took either 1.5 mg of LNG as a single dose or in two doses 12 h apart, up to 120 h of unprotected intercourse. Contraceptive efficacy (pregnancy rates) at different weight and BMI categories was evaluated.ResultsOverall pregnancy rate was low at 1.2%. Pregnancy rates were also low in women weighing over 80 kg (0.7%) and who were obese (BMI over 30 kg/m2) (2.0%). The pooled analyses for pregnancy demonstrated that BMI over 30 kg/m2 decreased efficacy significantly (odds ratio 8.27, 95% confidence interval = 2.70–25.37) when compared to women in lower BMI categories, mainly influenced by pregnancies in obese women from one study site. Sensitivity analyses excluding that site showed that obesity was no longer a risk factor; however, the other studies included too few obese women in the sample to exclude a substantial decrease in efficacy.ConclusionsPregnancy rates with use of LNG 1.5 mg for EC were low at less than 3% across different weight and BMI categories. Pooled analyses showed an increase in pregnancy rates among obese women (BMI more than 30 kg/m2) compared to women with normal BMI levels, influenced by pregnancies all coming from one study site.ImplicationsAccess to LNG as EC should still be promoted to women who need them, and not be restricted in any weight or BMI category, with additional attention for counselling and advice for obese women.