Gastric mucosal irritation following oral exposure to sodium metabisulphite: A reproducible effect?
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- 作者：Rosalind R. Dalefielda ; rosalind.dalefield@foodstandards.govt.nz" class="auth_mail" title="E-mail the corresponding author ; Utz Muellerb ; utz.mueller@apvma.gov.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sodium metabisulphite ; Sulphite
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：277-282
- 全文大小：232 K
文摘
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A 7-day dose range-finding study of dietary sodium metabisulphite (SM) was conducted in male Sprague-Dawley rats.
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Rat feed with SM at concentrations of 0.25%, 0.5%, 1% or 4% (w/w) was prepared daily.
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Resulting group mean sulphite consumptions were 90, 198, 390 and 1478 mg SO2-equivalent/kg bodyweight/day respectively.
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Group mean feed consumption was marginally depressed in rats in the 4% group but bodyweight gain was markedly decreased.
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There was no histopathological evidence of treatment-related lesions of the gastric mucosa in any rats.
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These results challenge the reproducibility of stomach lesions following sulphites ingestion.