Structure and function of mitochondrial supercomplexes
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- 作者：Natalya V. Dudkina ; Roman Kouř ; il ; Katrin Peters ; Hans-Peter Braun ; Egbert J. Boekema
- 关键词：Oxidative phosphorylation ; Mitochondria ; Respirasome ; ATP synthase ; Electron microscopy ; Supercomplex
- 刊名：Biochimica et Biophysica Acta (BBA)/Bioenergetics
- 出版年：2010
- 出版时间：June-July 2010
- 年：2010
- 卷：1797
- 期：6-7
- 页码：664-670
- 全文大小：1103 K
文摘
The five complexes (complexes I–V) of the oxidative phosphorylation (OXPHOS) system of mitochondria can be extracted in the form of active supercomplexes. Single-particle electron microscopy has provided 2D and 3D data describing the interaction between complexes I and III, among I, III and IV and in a dimeric form of complex V, between two ATP synthase monomers. The stable interactions are called supercomplexes which also form higher-ordered oligomers. Cryo-electron tomography provides new insights on how these supercomplexes are arranged within intact mitochondria. The structure and function of OXPHOS supercomplexes are discussed.