UPLC-MS/MS method with automated on-line SPE for the isomer-specific quantification of the first-generation anti-HCV protease inhibitors in peripheral blood mononuclear cells
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- 作者：Amedeo De Nicolò ; ; 1 ; amedeo.denicolo@unito.it" class="auth_mail" title="E-mail the corresponding author ; Adnan Mohamed Abdi1 ; Lucio Boglione ; Lorena Baiett ; Sarah Allegra ; Giovanni Di Perri ; Antonio D&rsquo ; Avolio
- 关键词：Tandem-mass ; HCV ; Intracellular ; Boceprevir ; Telaprevir ; Chromatography
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：115
- 期：Complete
- 页码：443-449
- 全文大小：631 K
文摘
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Method applying the new automated OSM platform.
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First fully validated method capable of quantifying boceprevir and telaprevir in PBMCs.
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High resolution separation of drugs diastereoisomers.
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Capability for routine application and sample-specific standardization of results.
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First description of boceprevir and telaprevir compartmentalization in PBMCs.