• 作者：Lucio Boglione ; Claudia Spezia ; Filippo Lipani ; Rosanna Balbiano ; Francesca Canta ; Rosalia Marrone ; Maura De Agostini ; Guido Calleri ; Pietro Caramello
• 关键词：Klebsiella pneumoniae ; Meningitis ; Endophtalmitis ; Taiwan ; South-East Asia
• 刊名：Travel Medicine and Infectious Disease
• 出版年：2008
• 出版时间：January-March 2008
• 年：2008
• 卷：6
• 期：1-2
• 页码：32-35
• 全文大小：193 K

Methods

In this 12-year retrospective study, 117 adult patients were identified with culture-proven CABM. A comparison was made between the clinical data of the patients with and without seizures during hospitalization.

Results

Thirty-one patients had seizures during CABM, accounting for 27 % (31/117) of the episodes. The time interval between the onset of bacterial meningitis and the seizures was 1–21 days (mean, 4 days). Furthermore, 80 % (25/31) of the episodes occurred within 24 h of presentation. Ten patients who had seizures progressed to status epilepticus. At follow-up after completing treatment, 10 patients completely recovered and were seizure-free, 19 died of meningitis during the acute stage and the other two progressed to chronic epilepsy.

Conclusion

A log-rank test demonstrated that the long-term outcome of adult CABM with acute seizures produced worse outcomes than for those who had no seizures, though no difference was noted between focal and generalized seizures. None of our patients without seizures in the acute phase of bacterial meningitis developed late seizures during the follow-up periods. Poor outcome in this study may attribute to neurological complications such as seizure, hydrocephalus, infection itself, or a combination of complications.