Role of IL28-B polymorphisms in the treatment of chronic hepatitis B HBeAg-negative patients with peginterferon

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• 作者：Lucio Boglione ; Jessica Cusato ; Sarah Allegra ; Isabella Esposito ; Francesca Patti ; Giuseppe Cariti ; Giovanni Di Perri ; Antonio D鈥橝volio
• 关键词：HBV ; hepatitis B virus ; HCC ; hepatocellular carcinoma ; NA ; nucleos(t)ide analogues ; CHB ; chronic hepatitis B ; PEG-INF ; pegylated interferon ; HBsAg ; hepatitis B surface antigen ; ALT ; alanine aminotransferase ; HBeAg ; hepatitis e antigen ; SVR ; sustained virological response ; cccDNA ; closed circular DNA ; UNL ; upper normal level ; qHBsAg ; quantitative HBsAg ; IQR ; inter-quartile range ; SNP ; single nucleotide polymorphism
• 刊名：Antiviral Research
• 出版年：February, 2014
• 年：2014
• 卷：102
• 期：Complete
• 页码：35-43
• 全文大小：769 K

文摘

Interleukin (IL)28-B polymorphism has been related to interferon response in the treatment of hepatitis C, but its role in chronic hepatitis B (CHB) therapy is still poorly understood.

We aimed to investigate the effect of IL28-B polymorphisms in the treatment with pegylated-interferon (PEG-IFN) of patients with CHB.

We retrospectively analyzed 190 patients with chronic hepatitis B e antigen (HBeAg) negative, genotype A (22%), B (12%), C (10%), D (33%), E (20%), treated with PEG-IFN alfa-2a for 48 weeks; genotype analysis was performed for IL28-B polymorphisms , and according to virological, serological and biochemical response.

During 2 years of follow-up 12 patients (6.3%) cleared hepatitis B surface antigen (HBsAg) with seroconversion, 40 (21%) obtained a negative viral load and 104 (54.7%) gained a biochemical response. We found a difference of distribution of CC genotype among different ethnicity (p = 0.013). CC genotype was significantly associated with serological and virological response (p < 0.001); TT and AA genotypes were mostly related with virological response (p < 0.001). In multivariate logistic analysis CC was predictive of virological response (OR = 4.290; CI = 1.589-11.580, p = 0.004) and serological response (OR = 10.129; CI = 2.440-42.044; p < 0.001). TT was predictive only of virological response (OR = 3.746, CI = 1.235-11.355; p = 0.020). The E genotype was a negative predictive factor of virological response (OR = 0.057; CI = 0.014-0.238; p < 0.001).

IL28-B polymorphisms are related to different response in the treatment of CHB HBeAg-negative with PEG-IFN, and the E genotype is a novel negative predictive factor.