Expression and partial biochemical characterization of a recombinant serine protease from Bothrops pauloensis snake venom
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- 作者：Thais F. Isabela ; Guilherme Nunes Moreira Costaa ; Isabela B. Pachecoa ; Luana G. Barbosaa ; Cé ; lio D. Santos-Juniora ; Fernando P.P. Fonsecab ; Johara Boldrini Franç ; ac ; Flá ; vio Henrique-Silvab ; Kelly A.G. Yoneyamaa ; Renata S. Rodriguesa ; d ; rsrodrigues@ingeb.ufu.br" class="auth_mail" title="E-mail the corresponding author ; Veridiana de Melo Rodriguesa ; d
- 关键词：Bothrops pauloensis ; Snake venom ; Thrombin-like ; serine protease ; Heterologous expression
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：115
- 期：Complete
- 页码：49-54
- 全文大小：1091 K
文摘
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rBpSP-II showed sequence identity ranging from 83% to 96% to other snake venom serine proteases.
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rBpSP-II showed activity on chromogenic substrates demonstrated thrombin-like activity.
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rBpSP-II can serve as template for synthesis of therapeutic agents to treat hemostatic disorders.