Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming
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- 作者：Sö ; ren Boller1 ; 4 ; Senthilkumar Ramamoorthy1 ; 4 ; Duygu Akbas1 ; 4 ; Robert Nechanitzky1 ; Lukas Burger2 ; 3 ; Rabih Murr2 ; Dirk Schü ; beler2 ; Rudolf Grosschedl1 ; grosschedl@ie-freiburg.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：EBF1 ; chromatin ; B lymphopoiesis ; DNaseI hypersensitivity ; DNA methylation ; pioneer transcription factor
- 刊名：Immunity
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：44
- 期：3
- 页码：527-541
- 全文大小：6888 K
文摘
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EBF1 induces chromatin accessibility and DNA demethylation in naive chromatin
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C-terminal domain (CTD) of EBF1 is required for the regulation of a specific gene set
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CTD-dependent genes are involved in B cell fate decision and differentiation
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CTD enables EBF1 to access progenitor chromatin at sites with low TF co-occupancy