- 作者：Veronica Salvatore ; Alberto Borghi ; alberto.borghi@unibo.it ; Eugenia Peri ; Antonio Colecchia ; Silvia Li Bassi ; Luciana Montrone ; Roberto Di Donato ; Fabio Conti ; Cristina Crespi ; Davide Festi ; Mauro Bernardi ; Pietro Andreone ; Luigi Bolondi
- 关键词：Fibroscan ; Hepatic artery resistance index ; Hepatic fibrosis ; Splenic artery resistance index
- 刊名：Digestive and Liver Disease
- 出版年：2012
- 出版时间：February 2012
- 年：2012
- 卷：44
- 期：2
- 页码：154-159
- 全文大小：318 K
Aim
We tested the relationship between hepatic haemodynamics assessed by Doppler ultrasonography and liver stiffness assessed by Transient Elastography in hepatitis C related chronic liver disease.Methods
Three liver Doppler ultrasound parameters (hepatic artery resistance index, splenic artery resistance index and waveform pattern in hepatic veins) and liver stiffness measured by Transient Elastography were analysed in one hundred consecutive patients affected by hepatitis C related chronic liver disease.
Results
Hepatic and splenic arteries resistance indexes correlate significantly (p < 0.0001 for both) with liver stiffness. A hepatic artery resistance index cut-off value of 0.64 provided sensitivity and specificity respectively of 84.4 % and 69.1 % for predicting liver stiffness ¡Üor >13 kPa, whereas a splenic artery resistance index cut-off value of 0.56 provided sensitivity and specificity respectively of 81.3 % and 48.5 % . The coincidental finding of both resistance indexes above the respective cut-off values showed a good accuracy in identifying patients with liver stiffness values >13 kPa (accuracy = 78 % , +LR = 2.90, ?LR = 0.31).
A significant difference in liver stiffness values was evident between patients with triphasic and bi- or monophasic waveform pattern (p = 0.005).
Conclusions
Hepatic and splenic arteries resistance indexes and the hepatic veins waveform pattern assessed by Doppler ultrasound may provide information similar to that of Transient Elastography in hepatitis C related chronic liver disease.