Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6
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- 作者：Yuan-Chin Tsaia ; Wei-Yu Chenb ; c ; Man Kit Siua ; d ; Hong-Yuan Tsaia ; Juan Juan Yine ; Jiaoti Huangf ; Yen-Nien Liua ; liuy@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：ETV6 ; Epidermal growth factor receptor (EGFR) ; microRNA (miR)-96 ; Prostate cancer ; Bone metastasis
- 刊名：Cancer Letters
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：384
- 期：Complete
- 页码：1-8
- 全文大小：2918 K
文摘
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EGFR induces miR-96 by a physical interaction at the promoter region of miR-96.
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miR-96 targets to ETV6 transcript and reduces its stability.
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ETV6 is downregulated by EGFR-miR-96 signaling.
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The reduced ETV6 levels are associated with malignant prostate cancer.
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ETV6 acts as a tumor suppressor inhibiting prostate cancer metastasis.