The paraoxonase promoter polymorphism (−107)T>C is not associated with carotid intima-media thickness in Sicilian hypercholesterolemic patients

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• 作者：Campo ; Salvatore ; Sardo ; Maria A. ; Trimarchi ; Giuseppe ; Bonaiuto ; Michele ; Castaldo ; Maria ; et. al.
• 关键词：Paraoxonase polymorphism ; Carotid intima-media thickness ; PON1 ; (&minus ; 107)T> ; C ; Q192R ; L55M
• 刊名：Clinical Biochemistry
• 出版年：2004
• 出版时间：May, 2004
• 年：2004
• 卷：37
• 期：5
• 页码：388-394
• 全文大小：129 K

文摘

Background and Objectives. Increased plasma low-density lipoprotein-cholesterol (LDL-C) levels in hypercholesterolemic subjects are associated with enhanced LDL oxidation that represents an additional risk for atherosclerotic disease. Human serum paraoxonase (PON1), a high-density lipoprotein (HDL) associated enzyme, has been shown to protect LDL from oxidation, thus playing an important role in reducing the risk of atherosclerosis. PON1 gene polymorphisms have been found to be associated with the variations in serum PON1 levels and activities, and with the risk for coronary artery disease (CAD). This study was performed to evaluate the contribution of the PON1 promoter (−107)T>C and the coding region Gln 192 Arg (Q192R) and Leu 55 Met (L55M) polymorphisms to the presence of carotid atherosclerosis in 208 Sicilian subjects with primary hypercholesterolemia.