Effects of gallopamil on epinephrine and norepinephrine plasmatic levels and on txb₂ and beta-tg release in patients with coronary artery disease during adrenergic stimulus with cold pressor test

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• 作者：Antonino Saitta ; Michele Bonaiuto ; Angelo Mileto ; Francesco Squadrito ; Giuseppe M. Campo ; Domenica Altavilla ; Giuseppe Giordano ; Giovanni Squadrito ; Salvatore Totaro ; Maurizio Cinquegrani ; Giuseppe Squadrito
• 刊名：Pharmacological Research
• 出版年：1995
• 出版时间：July-August 1995
• 年：1995
• 卷：32
• 期：1-2
• 页码：49-55
• 全文大小：616 K

文摘

We investigated the effect of gallopamil administration during a cold pressor test (CPT) in 18 patients suffering from chronic angina (CA) and in 21 healthy subjects. CA patients showed increased basal levels of beta-thromboglobulin and thromboxane B₂ compared to control patients and normal plasma levels of catecholamines. CPT caused plasma catecholamines, beta-thromboglobulin and TxB₂ levels to rise. This rise was greater in CA patients than in control patients. Administration of gallopamil (50 mg kg⁻¹ three times a day for 30 days) reduced plasma levels of catecholamines, beta-thromboglobulin and TxB₂ blood concentrations either under basal conditions or after CPT. Our data suggest that gallopamil is able to modulate the response induced by adrenergic stress.