Hypothalamic orexin’s role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model
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- 作者：Lauren M. Federicia ; b ; c ; Izabela Facco Calimana ; b ; Andrei I. Moloshb ; d ; Stephanie D. Fitza ; William A. Truitta ; b ; Pascal Bonaventuree ; Janet S. Carpenterf ; Anantha Shekharb ; d ; Philip L. Johnsona ; b ; philjohn@iupui.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Orexin ; Hypocretin ; Hypothalamus ; Hot flash ; Estrogen ; Menopause ; Thermoregulation ; Cutaneous ; Serotonin ; Norepinephrine
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：127-137
- 全文大小：3789 K
文摘
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Anxiogenic drug elicits exacerbated tail skin temperature responses in OVEX rats.
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Estrogen replacement reduces tail skin temperature responses to anxiogenic drug.
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Orexin neurons and efferent targets show exacerbated response to anxiogenic drug.
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Orexin expression elevated in perifornical hypothalamus of OVEX rats.
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Orexin receptor antagonists reduce tail skin temperature responses to anxiogenic drug.