Chemical constituents of Stereospermum acuminatissimum and their urease and ¦Á-chymotrypsin inhibitions

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• 作者：Kamdem Soup T.  ; Ramsay^a ;   ; ^b ; Pascal  ; Wafo^a ;   ; ^{wafopascal@yahoo.fr} ; Zulfiqar  ; Ali^b ;   ; ^c ;   ; ^{zulfiqar@olemiss.edu} ; Ajmal  ; Khan^b ; Ogbole O.  ; Oluyemisi^d ; Bishnu P.  ; Marasini^b ; Ikhlas A.  ; Khan^c ; Ngadjui T.  ; Bonaventure^e ; M. Iqbal  ; Choudhary^b ;   ; Atta-ur-Rahman^b
• 关键词：Stereospermum acuminatissimum ; Bignoniaceae ; Guanine derivatives ; Urease inhibition ; Chemotaxonomy
• 刊名：Fitoterapia
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：83
• 期：1
• 页码：204-208
• 全文大小：391 K

文摘

Phytochemical investigation of the stem bark of Stereospermum acuminatissimum K. Schum. resulted in the isolation of 21 compounds, including two new guanine derivatives, 1,3,7-trimethylguanin-1/3-ium (1) and 3,7-dimethylguanin-1/3-ium (2), and one new phenolic long chain ester, 2-(4-hydroxyphenyl)ethyl hentriacontanoate (3). The known compounds were identified as sterequinones A, F, and H (4, 5, and 6), zenkequinones A-B (7?b xmlns="""">8), p-coumaric acid (9), methyl caffeate (10), caffeic acid (11), psilalic acid (12), syringaldehyde (13), norviburtinal (14), specioside (15), verminoside (16), tyrosol (17), eutigoside A (18), ellagic acid (19), atranorin (20), and ursolic acid (21). The metabolites were screened for their potential against urease and ¦Á-chymotrypsin enzymes, as urease is targeted in peptic ulcer while ¦Á-chymotrypsin is used to remove protein debris in ulcer. Compound 20 was found to be excellent urease inhibitor with IC₅₀ value of 18.2 ¡À 0.03 ¦ÌM. Compounds 13 and 18?b xmlns="""">20 are reported for the first time from the genus Stereospermum. The chemotaxonomic significance of the isolated compounds was also described.