Aspirin resistance determined with PFA-100 does not predict new thrombotic events in patients with stable ischemic cerebrovascular disease

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• 作者：Giorgio B. Boncoraglio ; Antonella Bodini ; Carla Brambilla ; Elena Corsini ; Maria R. Carriero ; Eugenio A. Parati
• 关键词：Aspirin resistance ; PFA-100 ; Ischemic stroke ; TIA ; Cerebrovascular disease
• 刊名：Clinical Neurology and Neurosurgery
• 出版年：2009
• 出版时间：April 2009
• 年：2009
• 卷：111
• 期：3
• 页码：270-273
• 全文大小：151 K

文摘

Objective

Evidence is growing that some patients are not responsive to the antithrombotic action of aspirin. We prospectively evaluated the ability of aspirin resistance status, determined by PFA-100, to predict new thrombotic events in patients with stable ischemic cerebrovascular disease.

Methods

We studied 129 consecutive patients with stroke, transient ischemic attack (TIA) or vascular cognitive impairment. We assessed relationships between aspirin resistance, risk factors for ischemic cerebrovascular disease, and occurrence of new thrombotic events (composite of stroke, TIA, myocardial infarction, and cardiovascular death).

Results

Aspirin resistance, found in 26 (20.1 % ) cases, was unrelated to any of the examined vascular risk factors. During mean follow-up of 56 months, new thrombotic events occurred in 19 patients (14.7 % ), four with aspirin resistance (15.4 % ) and 15 (14.6 % ) without aspirin resistance (p = 1.00).

Conclusion

Aspirin resistance determined by PFA-100 does not predict new thrombotic events in patients with stable ischemic cerebrovascular disease.