The ins and outs of lncRNA structure: How, why and what comes next?
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- 作者：Amanda J. Blythea ; amanda.blythe@uwa.edu.au" class="auth_mail" title="E-mail the corresponding author ; Archa H. Foxb ; Charles S. Bonda ; charles.bond@uwa.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：LncRNA ; Structure ; RNA structure ; RNA-protein interaction ; Structural biology ; non-coding
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1859
- 期：1
- 页码：46-58
- 全文大小：2452 K
文摘
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lncRNA is the least characterised class of RNA in terms of structure and function.
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Structural studies of lncRNA are highly challenging.
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Current structural analysis techniques are not well suited to the lncRNA field.
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Structural determination of lncRNA is critical to reveal their molecular mechanism.
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Future developing technologies will enable high-resolution structures of lncRNA.