Levodopa and neuropathy risk in patients with Parkinson disease: Effect of COMT inhibition
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- 作者：Giovanni Cossua ; giovannicossu1@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Roberto Ceravolob ; Maurizio Zibettic ; Roberta Arcaa ; Valeria Ricchia ; Alessandra Paribelloa ; Daniela Murgiaa ; Aristide Merolac ; Alberto Romagnoloc ; Valentina Nicolettib ; Giovanni Palermob ; Alessandra Mereud ; Leonardo Lopianoc ; Maurizio Melisa ; Giovanni Abbruzzesee ; Ubaldo Bonuccellib
- 关键词：Parkinson's disease ; Peripheral neuropathy ; Levodopa ; COMT inhibition
- 刊名：Parkinsonism & Related Disorders
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：27
- 期：Complete
- 页码：81-84
- 全文大小：234 K
文摘
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A possible protective ICOMT effect on the development of LD-induced neuropathy is evaluated.
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In patients on LD + entacapone the prevalence of neuropathy was reduced compared to ld-alone group.
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Laboratory tests suggest a drug effect in the rebalancing of the one-carbon-cycle.
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The protective effect of ICOMT seems related on the duration of combination therapy.