Relationship between neuropsychological impairment and grey and white matter changes in adult-onset myotonic dystrophy type 1

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• 作者：Sigrid Baldanzi^a ; ¹ ; Paolo Cecchi^b ; ¹ ; Serena Fabbri^b ; Ilaria Pesaresi^b ; Costanza Simoncini^a ; Corrado Angelini^c ; Ubaldo Bonuccelli^a ; Mirco Cosottini^b ; ^d ; Gabriele Siciliano^a ; ^{g.siciliano@med.unipi.it}
• 关键词：MR imaging ; VBM ; TBSS ; DM1 ; Neuropsychology
• 刊名：NeuroImage: Clinical
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：190-197
• 全文大小：1449 K
• 卷排序：12

文摘

We performed VBM and TBSS analyses in a sample of adult-onset DM1 patients. The relationship between neuroimaging variables and cognitive profile was studied. Global atrophy correlated with executive and visuo-spatial abilities. TBSS revealed associations between DTI indexes and cognitive performances. Disrupted complex neuronal networks can underlie cognitive dysfunction in DM1.