Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells
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- 作者：Boon Chin Heng ; PhD&lowast ; ; Xin Ye ; MSc&lowast ; ; &dagger ; ; &Dagger ; ; Yuan Liu ; MSc&lowast ; ; § ; ; Waruna Lakmal Dissanayaka ; BDS ; PhD&lowast ; ; § ; ; Gary Shun Pan Cheung ; MDS ; PhD&lowast ; ; Chengfei Zhang ; DDS ; PhD&lowast ; ; § ; ; zhangcf@hku.hk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Bcl2 ; dental pulp stem cells ; osteogenic differentiation ; proliferation
- 刊名：Journal of Endodontics
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：42
- 期：4
- 页码：575-583
- 全文大小：1232 K
文摘
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Bcl2 is known to play key roles in regulating cell survival and apoptosis.
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Overexpression of Bcl2 resulted in higher cell densities of dental pulp stem cells (DPSCs) in in vitro culture.
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Overexpression of Bcl2 inhibited DPSCs apoptosis.
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Overexpression of Bcl2 inhibited osteogenic/odontogenic differentiation of DPSCs.