Functional imaging in liver tumours

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• 作者：Maxime Ronot¹ ; ² ; ³ ; Ashley Kieran Clift⁴ ; Valé ; rie Vilgrain¹ ; ² ; ³ ; ^{valerie.vilgrain@aphp.fr" class="auth_mail" title="E-mail the corresponding author} ; Andrea Frilling⁴
• 关键词：DW ; diffusion-weighted ; MRI ; magnetic resonance imaging ; CE ; contrast-enhanced ; US ; ultrasound ; CT ; computed tomography ; PET ; positron emission tomography ; HCC ; hepatocellular carcinoma ; MFC ; mass-forming cholangiocarcinoma ; OATP ; organic anionic transporting polypeptides ; MRPs ; multidrug resistance proteins ; Gd-BOPTA ; Gadobendate dimeglumine ; Gd-EOD-OTPA ; Gadoxetic acid ; ADC ; apparent diffusion coefficient ; 18F-FDG ; 18F-fluorodeoxyglucose ; 18F-FLT ; 18F-fluorothymidine ; LM ; liver metastases ; CRC
• 刊名：Journal of Hepatology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：65
• 期：5
• 页码：1017-1030
• 全文大小：1741 K

文摘

Functional imaging encompasses techniques capable of assessing physiological parameters of tissues, and offers useful clinical information in addition to that obtained from morphological imaging. Such techniques may include magnetic resonance imaging with diffusion-weighted sequences or hepatobiliary contrast agents, perfusion imaging, or molecular imaging with radiolabelled tracers. The liver is of major importance in oncological practice; not only is hepatocellular carcinoma one of the malignancies with steadily rising incidence worldwide, but hepatic metastases are regularly observed with a range of solid neoplasms. Within the realm of hepatic oncology, different functional imaging modalities may occupy pivotal roles in lesion characterisation, treatment selection and follow-up, depending on tumour size and type. In this review, we characterise the major forms of functional imaging, discuss their current application to the management of patients with common primary and secondary liver tumours, and anticipate future developments within this field.