The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain
详细信息 查看全文
- 作者：Biswaranjan Mohanty1 ; 3 ; Stephanie Helder1 ; Ana P.G. Silva1 ; Joel P. Mackay1 ; joel.mackay@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Daniel P. Ryan2 ; daniel.ryan@anu.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：PDB ; protein data bank ; CHD ; chromodomain helicase DNA-binding protein ; ISWI ; imitation switch ; CHCT ; CHD1 helical C-terminal domain ; EMSA ; electrophoretic mobility shift assay ; PNK ; polynucleotide kinase ; HMM ; hidden Markov model ; NOE ; nuclear Overhauser effect ; GSH ; glutathione ; PP1D ; protein phosphatase 1D ; CATH ; class ; architecture ; topology and homology ; BLAST ; basic local alignment search tool ; TBE ; Tris-borate EDTA ; SANT ; Swi3 ; Ada2 ; N-CoR ; TFIIIB ; SLIDE ; SANT-like ISWI domain ; BRK ; BRM a
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：23 October 2016
- 年：2016
- 卷：428
- 期：21
- 页码：4298-4314
- 全文大小：2958 K
文摘
- •
CHD1 is a conserved chromatin remodelling enzyme important for transcription.
- •
An NMR structure of an unrecognised helical domain (CHCT) in CHD1 is reported.
- •
The CHCT domain can bind DNA and nucleosomes.
- •
The CHCT domain is also found in the uncharacterised C17orf64 proteins.
- •
These results enhance our structural understanding of CHD1 enzymes.