Hypogonadism and Sex Steroid Replacement Therapy in Girls with Turner Syndrome

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• 作者：Aneta Gawlik ; MD ; PhD¹ ; ² ; ^{agawlik@mp.pl" class="auth_mail" title="E-mail the corresponding author} ; Magdalena Hankus ; MD² ; Kamila Such ; MD³ ; Agnieszka Drosdzol-Cop ; MD ; PhD⁴ ; Paweł Madej ; MD ; PhD⁵ ; Marzena Borkowska ; MD⁶ ; Agnieszka Zachurzok ; MD¹ ; ² ; Ewa Malecka-Tendera ; MD ; PhD¹ ; ²
• 关键词：Hypogonadism ; Sex steroid replacement therapy ; Sex hormone replacement therapy (HRT) ; Turner syndrome
• 刊名：Journal of Pediatric and Adolescent Gynecology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：29
• 期：6
• 页码：542-550
• 全文大小：927 K

文摘

Turner syndrome is the most common example of hypergonadotropic hypogonadism resulting from gonadal dysgenesis. Most patients present delayed, or even absent, puberty. Premature ovarian failure can be expected even if spontaneous menarche occurs. Laboratory markers of gonadal dysgenesis are well known. The choice of optimal hormone replacement therapy in children and adolescents remains controversial, particularly regarding the age at which therapy should be initiated, and the dose and route of estrogen administration. On the basis of a review of the literature, we present the most acceptable schedule of sex steroid replacement therapy in younger patients with Turner syndrome.