Degradation kinetics of peptide-coupled alginates prepared via the periodate oxidation reductive amination route

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• 作者：Marianne Ø ; . Dalheim ^{marianne.dalheim@ntnu.no} ; Ann-Sissel T. Ulset ^{ann-sissel.t.ulset@ntnu.no} ; Ina Beate Jenssen ^{ina.b.jenssen@ntnu.no} ; Bjø ; rn E. Christensen ; ^{bjorn.e.christensen@ntnu.no}
• 关键词：POA ; periodate oxidized alginate ; POM ; periodate oxidized mannuronan ; POAr/POMr ; borohydride reduced POA/POM ; MeOTyr ; l-tyrosine methyl ester ; P0 ; periodate/alginate molar ratio ; DMeOTyr ; degree of substitution of MeOTyr
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：1844-1852
• 全文大小：1271 K
• 卷排序：157

文摘

Alginate and mannuronan dialdehydes prepared by periodate oxidation (4 and 8% oxidation). Model peptide (methyl tyrosine ester) attached by reductive amination. Influence of substitution on alginate stability determined by SEC-MALS. Stability profiles reflect the distribution of peptide attachment at C2 or C3. Relevance to stability of alginate biomaterials discussed.