New glutathione peroxidase mimetics—Insights into antioxidant and cytotoxic activity

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• 作者：Agata J. Pacuła^a ; Katarzyna B. Kaczor^b ; Angelika Wojtowicz^b ; Jędrzej Antosiewicz^b ; Anna Janecka^c ; Angelika Długosz^c ; Tomasz Janecki^d ; Jacek Ścianowski^a ; ^{jsch@chem.umk.pl}
• 关键词：Benzisoselenazolones ; Diselenides ; Antioxidant activity ; Cytotoxicity
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：126-131
• 全文大小：935 K
• 卷排序：25

文摘

A series of N-alkyl benzisoselenazol-3(2H)-ones has been obtained and transformed to corresponding diselenides by the reduction with sodium borohydride. Additionally, efficient methodology for the oxidative Se–N bond formation by potassium iodate has been presented, new conversion of diselenide to benzisoselenazolone was observed. The GPx-like activity of all synthetized derivatives has been evaluated by NMR. N-Allyl diselenide was up to five times better antioxidant than ebselen. Anticancer capacity towards MCF7 and DU145 cancer cells has been also tested. The highest antiproliferative activity was obtained for N-cyclohexyl benzisoselenazolone.