Enantiomerically pure piperazines via NaBH₄/I₂ reduction of cyclic amides

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• 作者：Vagala Harish ; Mariappan Periasamy ; ^{mpsc@uohyd.ac.in}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：175-180
• 全文大小：1456 K
• 卷排序：28

文摘

Enantiomerically pure (3S,7R,8aS)-3-phenyloctahydropyrrolo[1,2-a]pyrazine-7-ol, (3S,7R,8aS)-3-methyl octahydropyrrolo[1,2-a]pyrazine-7-ol, (3S,7R,8aS)-3-isopropyloctahydropyrrolo[1,2-a]pyrazine-7-ol and (3S,7R,8aS)-3-isobutyloctahydropyrrolo[1,2-a]pyrazine-7-ol 16d were synthesized via preparation of the corresponding cyclic amides from enantiomerically pure l-proline and hydroxyproline derivatives followed by reduction using sodium borohydride-iodine.