Fumarates and Cancer

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• 作者：Gwenny M. Fuhler¹ ; ^{g.fuhler@erasmusmc.nl} ; Hester Eppinga¹ ; Maikel P. Peppelenbosch¹
• 关键词：fumarate ; cancer ; metastasis ; epithelial-to-mesenchymal transition
• 刊名：Trends in Molecular Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：3-5
• 全文大小：592 K
• 卷排序：23

文摘

Accumulation of intermediate metabolites of the tricarboxylic acid (TCA) cycle in tumor cells can cause epithelial-to-mesenchymal transition (EMT), although the exact mechanisms remain elusive. Recent studies show that the oncometabolite fumarate, which accumulates in fumarate hydratase-deficient renal cancers, confers tumor aggressiveness by causing epigenetic changes in the antimetastatic miRNA cluster mir-200ba429. This may have important implications for the use of fumarates in the clinic.