Disarray of glomerular and tubular cell adhesion molecules in the course of experimental Bothrops moojeni envenomation

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• 作者：Carla Beatriz Collares-Buzato ; Maria Alice da Cruz-H枚fling
• 关键词：Acute kidney injury ; Bothropic envenomation ; Cell adhesion proteins ; Cytoskeletal proteins ; Glomerular injury ; Nephron tubular injury
• 刊名：Toxicon
• 出版年：February, 2014
• 年：2014
• 卷：78
• 期：Complete
• 页码：41-46
• 全文大小：1629 K

文摘

In this study, we show that administration of Bothrops moojeni venom in rats induces a general disturbance in the distribution and content of the tight junctional protein ZO-1, the cell-matrix receptor beta 1 integrin, the cytoskeletal proteins, vinculin and F-actin, and of the extracellular matrix component laminin in renal corpuscles and cortical nephron tubules. These findings suggest that cell-cell and cell-matrix adhesion proteins may be molecular targets in the B. moojeni-induced kidney injury.