Chloride channel antagonists perturb growth and morphology of Neurospora crassa

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• 作者：Hanke ; Guy T. ; Northrop ; Frederick D. ; Devine ; Gary R. ; Bothwell ; John H.F. ; Davies ; Julia M.
• 关键词：Channel block ; Fungistasis ; Niflumic acid ; pH ; A9C ; anthracene-9-carboxylic acid ; CTC ; chlortetracycline ; EA ; ethacrynic acid ; I₅₀ ; concentration effecting 50 % inhibition ; MM(A)S ; minimal medium (with agar) plus sucrose ; NA ; niflumic acid
• 刊名：FEMS Microbiology Letters
• 出版年：2001
• 出版时间：July 24, 2001
• 年：2001
• 卷：201
• 期：2
• 页码：243-247
• 全文大小：502 K

文摘

The chloride channel antagonists anthracene-9-carboxylic acid, ethacrynic acid and niflumic acid were found to be fungistatic and morphogenic when tested against the ascomycete Neurospora crassa. Potency increased with decreasing pH, suggesting that the protonated forms of the compounds were active. Niflumic acid produced the most pronounced growth aberrations which may reflect an ability to acidify the cytoplasm and block the plasma membrane anion channel of N. crassa.