The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation
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- 作者：Wook-Jin Chae1 ; Allison K. Ehrlich2 ; Pamela Y. Chan1 ; Alexandra M. Teixeira3 ; Octavian Henegariu4 ; Liming Hao3 ; Jae Hun Shin1 ; Jong-Hyun Park1 ; Wai Ho Tang5 ; Sang-Taek Kim6 ; Stephen E. Maher1 ; Karen Goldsmith-Pestana2 ; Peiying Shan7 ; John Hwa5 ; Patty J. Lee7 ; Diane S. Krause3 ; 8 ; 9 ; Carla V. Rothlin1 ; Diane McMahon-Pratt2 ; Alfred L.M. Bothwell1 ; alfred.bothwell@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：16 February 2016
- 年：2016
- 卷：44
- 期：2
- 页码：246-258
- 全文大小：4650 K
文摘
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Reduced expression of Dkk-1 protects the host from house-dust-mite-induced asthma
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Dkk-1 induces Th2 cell polarization and potentiates Th2 cell cytokine expression
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Platelets are the major source of Dkk-1 in pathological type 2 inflammation
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Pharmacological inhibition of Dkk-1 protects host from cutaneous leishmaniasis