Structural constraints-based evaluation of immunogenic avirulent toxins from Clostridium botulinum C2 and C3 toxins as subunit vaccines
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- 作者：A. Prisilla ; R. Prathiviraj ; R. Sasikala ; P. Chellapandi ; pchellapandi@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Point mutation ; Fold rate ; Molecular dynamic simulation ; ADP-ribosyltransferase ; Virulence ; Clostridium botulinum ; Immunotoxins ; C3 toxin ; Molecular docking ; Structural evolution ; C2 toxin
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：17-27
- 全文大小：1571 K
文摘
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Structural constraints in Clostridium botulinum C2 and C3 toxins and their mutants described.
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Hydrophobic and hydrogen bonding patterns determined structural stability of avirulent mutants.
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These mutants have stable backbone conformation with a common blue print of folding process
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We reported avirulent toxins as protein-based subunit vaccines/immunogens.