Drooling in Parkinson’s disease: A randomized controlled trial of incobotulinum toxin A and meta-analysis of Botulinum toxins
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- 作者：Pushpa Narayanaswamia ; pnarayan@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Thomas Geisbusha ; 1 ; thomas.geisbush@my.rfums.org" class="auth_mail" title="E-mail the corresponding author ; Andrew Tarullia ; 2 ; Andrew.Tarulli@atlantichealth.org" class="auth_mail" title="E-mail the corresponding author ; Elizabeth Raynora ; eraynor@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Shiva Gautamb ; sgautam@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Daniel Tarsya ; dtarsy@bidmc.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Gary Gronsethc ; ggronseth@kumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson&rsquo ; s disease ; Botulinum toxin ; Sialorrhea ; Clinical trials randomized controlled ; Clinical trials systematic reviews/meta-analysis
- 刊名：Parkinsonism & Related Disorders
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：73-77
- 全文大小：397 K
文摘
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Incobotulinum toxin A did not help drooling in Parkinson’s disease in this study.
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The study did not have precision to exclude a moderate benefit.
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The dose of Incobotulinum toxin A in the parotid glands may have influenced results.
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A meta-analysis of all studies shows that Botulinum toxin is useful for drooling in Parkinson’s disease.
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We discuss reasons for differences in the results of our study and previous studies.