Chemical study, antimalarial and antioxidant activities, and cytotoxicity to human breast cancer cells (MCF7) of Argania spinosa

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• 作者：Fatiha El Babili ; Jalloul Bouajila ; Isabelle Fouraste ; Alexis Valentin ; Severine Mauret ; Claude Moulis
• 关键词：Argania spinosa ; Sapotaceae ; Antimalarial ; Cytotoxicity ; Antioxidant ; MCF7
• 刊名：Phytomedicine
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：17
• 期：2
• 页码：157-160
• 全文大小：151 K

文摘

Introduction

In our work, we evaluate the potential antioxidant, antimalarial activity and also activity against human breast cancer cells (MCF7) of Argan fruit extracts using in vitro models to validate the traditional use of this plant. Its chemical composition was also studied to begin the understanding of its activities, waiting to find the structure-activity relationship.

Results

Polyphenols (89.4–218.5 eqGallic acid (mg/g dry)), tannins (39.3–214.0 eqCatechin (mg/g dry)), flavonoids (3.4–11.1 eqQuercetin (mg/g dry)) and anthocyanins (0.74–10.92 eqCyanindin (μg/g dry)) were quantified. A good (ethyl acetate and decoction) and moderate (petroleum ether) antioxidant activity were obtained for DPPH (IC₅₀ 32.3–600.8 μg/ml) and ABTS (IC₅₀ 11.9–988.8 μg/ml) assays. In addition, we found a good antimalarial activity (IC₅₀ 35 to >100 μg/ml) and human breast cancer cells activity (IC₅₀ 42 to >100 μg/ml).

Conclusions

The ethyl acetate extract and the decoction show interesting antimalarial and antioxidant activities. The results indicate a good correlations between anthocyanins quantitiy and the potential antioxidant (R²=0.9867) and also to antimalarial activity (R²=0.8175).