Percutaneous penetration and distribution of VX using in vitro pig or human excised skin: Validation of demeton-S-methyl as adequate simulant for VX skin permeation investigations
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- 作者：V. Vallet ; C. Cruz ; J. Licausi ; A. Bazire ; G. Lallement ; I. Boudry
- 关键词：VX ; Demeton-S-methyl (DSM) ; Paraoxon (POX) ; In vitro skin models ; Percutaneous absorption ; Simulant
- 刊名：Toxicology
- 出版年：2008
- 出版时间：3 April 2008
- 年：2008
- 卷：246
- 期：1
- 页码：73-82
- 全文大小：516 K
文摘
The organophosphorus (OP) chemical warfare V agent O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate (VX), is a highly toxic compound which mainly penetrates the body via percutaneous pathways. Hence, the following prerequisite: to ascertain compound absorption and percutaneous profile distribution with a view to further assessing the efficacy of topical skin protectants.