B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase
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- 作者：Amel Meguellatia ; b ; Abdelhakim Ahmed-Belkacemc ; Wei Yia ; b ; Romain Haudecoeura ; b ; Marie Crouillè ; rea ; b ; Rozenn Brilletc ; Jean-Michel Pawlotskyc ; d ; Ahcè ; ne Boumendjela ; b ; Marine Peuchmaura ; b ; Marine.Peuchmaur@ujf-grenoble.fr" class="auth_mail
- 关键词：Aurones ; Hepatitis C virus ; RNA-dependent RNA polymerase
- 刊名：European Journal of Medicinal Chemistry
- 出版年：10 June 2014
- 年：2014
- 卷：80
- 期：Complete
- 页码：579-592
- 全文大小：1624 K
文摘
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Various B-ring substituted aurones were synthetized.
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Aurones derivatives are allosteric inhibitors of HCV NS5B polymerase.
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Thumb pocket I of NS5B is the binding site for aurones analogues.
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Aurones bearing an indolyl as B-ring have the highest inhibitory effect (SAR study).
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Aurones analogues could be considered as potential hepatitis C antivirals.