Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis

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• 作者：Pagany ; Maria ; Jagodic ; Maja ; Bourquin ; Carole ; Olsson ; Tomas ; Linington ; Christopher
• 关键词：MOG ; EAE ; Tolerance ; Genetic susceptibility ; Protein expression ; BN ; Brown Norway ; CNS ; central nervous system ; DA ; Dark Agouti ; LEW ; Lewis ; MBP ; myelin basic protein ; MOG ; myelin oligodendrocyte glycoprotein ; MS ; multiple sclerosis ; PLP ; proteolipid prot
• 刊名：Journal of Neuroimmunology
• 出版年：2003
• 出版时间：June, 2003
• 年：2003
• 卷：139
• 期：1-2
• 页码：1-8
• 全文大小：481 K

文摘

Myelin oligodendrocyte glycoprotein (MOG) is encoded within the RT1.M region of the rat MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis (EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG–EAE is associated with higher expression of MOG mRNA and protein in the nervous system than in the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune system, but there was no correlation with disease susceptibility. These results suggest that differences in the expression of MOG in the target organ, rather than in the immune system may influence susceptibility to MOG–EAE.