Advances in stem cell therapy against gliomas

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• 作者：M. Sarah S. Bovenberg¹ ; ² ; ³ ; ^* ; M. Hannah Degeling¹ ; ² ; ³ ; ^* ; Bakhos A. Tannous¹ ; ² ; ^{btannous@hms.harvard.edu}
• 关键词：neural stem cells ; mesenchymal stem cells ; hematopoietic stem cells ; cell therapy ; glioma ; clinical trials ; gene therapy ; prodrug ; oncolytic virus
• 刊名：Trends in Molecular Medicine
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：19
• 期：5
• 页码：281-291
• 全文大小：2554 K

文摘

Malignant gliomas are one of the most lethal cancers, and despite extensive research very little progress has been made in improving prognosis. Multimodality treatment combining surgery, radiation, and chemotherapy is the current gold standard, but effective treatment remains difficult due to the invasive nature and high recurrence of gliomas. Stem cell-based therapy using neural, mesenchymal, or hematopoietic stem cells may be an alternative approach because it is tumor selective and allows targeted therapy that spares healthy brain tissue. Stem cells can be used to establish a long-term antitumor response by stimulating the immune system and delivering prodrug, metabolizing genes, or oncolytic viruses. In this review, we discuss current trends and the latest developments in stem cell therapy against malignant gliomas from both the experimental laboratory and the clinic.