Interdomain Communication of the Chd1 Chromatin Remodeler across the DNA Gyres of the Nucleosome

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• 作者：Ilana M. Nodelman¹ ; Franziska Bleichert² ; ³ ; Ashok Patel¹ ; ⁴ ; Ren Ren¹ ; Kyle C. Horvath¹ ; James M. Berger² ; Gregory D. Bowman¹ ; ⁵ ; ^{gdbowman@jhu.edu}
• 关键词：chromatin remodeling ; nucleosome sliding ; chromodomains ; SF2 ATPase ; superhelical location 2 ; SHL2 ; DNA unwrapping ; nucleosome assembly ; CHD remodeler ; ISWI remodeler
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：447-459.e6
• 全文大小：3410 K
• 卷排序：65

文摘

Cross-linking reveals unique positions of Chd1 domains on the nucleosome Positioning of the Chd1 DBD at the nucleosome edge is coupled to the ATPase motor The chromodomains contact nucleosomal DNA at SHL1 and pack against the ATPase and DBD Communication across DNA gyres provides a novel mechanism for sensing exit-side DNA